Jay does not want to give the new family moving in across the street the wrong impression and goes out of his way to make sure they know he is the best kind of neighbor, while Manny decides that the best way to an attractive and radical-thinking teenage girl's heart is through his actions. Meanwhile, at the Pritchett house, the entire family is using Alex's recent bout of mono to their advantage. Finally, Cam and Mitchell have always felt they were the most open, non-judgmental and supportive parents. However, when they overhear Lily insulting her new friend, they have to take a quick look in the mirror before they teach her a lesson about acceptance.
Alex suffers from Mono. She becomes a sort of slave for all their relatives because Claire uses her to yell at the others, Phil had a traumatic post experience after he locked accidentally in a closet and Luke wants to steal her homework for his final high school year. The only person who "cares" about her is Haley who refuses to admit she was fired.
Meanwhile, Jay installs security cameras in his backyard. He also handles his family problems as Manny wants to be a communist in order to please a girl, Joe wants to live outside and Gloria has issues with remotes. An afro-american family moves in and Jay wants to make sure that he is not racist.
Jay also helps Mitchell and Cameron realize that they're not open-minded as they believed they were when they asks him advice after they heared Lilly insult her new transgenre friend. It is then revealed that she made that because he mocked her dads's sexuality.
(The characters striked out do not appear in this episode)
- Jay Pritchett
- Gloria Pritchett
- Manny Delgado
- Joe Pritchett
- Claire Dunphy
- Phil Dunphy
- Haley Dunphy
- Alex Dunphy
- Luke Dunphy
- Mitchell Pritchett
- Cameron Tucker
- Lily Tucker-Pritchett
- This episode broadcasted exactly five years after Phil on Wire.
- This marks Alex's mono debut and this will continue until Halloween 4: The Revenge of Rod Skyhook even if it will be mentionned in Thanksgiving Jamboree that she is now cured.
- Alex is the first main character to have mono, but Phil mentioned in Sleeper that his roomate had it. Also, this marks Nicole and Warehouse Guy's second appearances.
- Warehouse Guy appears for the last time.
- Brent Jennings as Shawn
- Ernie Hudson as Miles
- Marsha Kramer as Margaret
- Jackson Millarker as Tom
- Danube Hermosillo as Frida
- Travis Guba as Security Guy
- Ian Bratschie as Warehouse Guy
- Lateefah Holder as Nicole
- Kasey Mahaffy as Dom