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Irene Pritchett is Donnie Pritchett's wife and also Michael Pritchett's mother, as well as the grandmother of Melanie Pritchett and the sister-in-law of Jay Pritchett.

In "Hawaii", Donnie mentioned over Jay's phone that Irene wa begging him, but Jay cut him off and goes after Gloria, so what she was begging of is unknown.

In "The Musical Man", Irene called her husband because he didn't tell her he landed safely, then later he told her "How the hell should I know where your glasses are?", and when Jay and Donnie made up and Donnie told Jay that he would be fine, he sayid that Irene lost 20 pounds due to stress.

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