Sophie Chambers was a girl Manny met and dated in "Won't You Be Our Neighbor" as well as the granddaughter of Jay's biggest business rival, Earl Chambers.
Manny met Sophie in his theater group and she appeared when Jay was demonstrating a new work idea of his and when Sophie noticed this, she revealed everything she knew about it, surprising Jay, but then Jay became furious when he found out that it was his biggest business rival, Earl Chambers who betrayed him years ago was Sophie's grandfather.
Jay forbade Manny to see her again, unlike Gloria, and tried to get Earl and Jay to work out their problems, but it seemed that their rivalry remained.
Sophie reappeared in "Halloween 4: The Revenge of Rod Skyhook" at a Halloween party, where she and Manny were seen talking.